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胃癌患者血清Endostatin和VEGF水平变化及意义 被引量:5

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摘要 1997年由哈佛大学O’Reilly等发现的内皮抑素(Endostatin)是胶原XⅧ的COOH2末端片段,为迄今为止所发现的最强的内源性血管生长抑制剂之一,可以完全抑制小鼠体内的肿瘤生长,而且反复使用没有耐药性的产生。但内皮抑素与胃癌的临床研究目前尚无报道,我们利用酶联免疫吸附法(ELISA)检测健康对照组及胃癌患者血清内皮抑素、VEGF的水平,探讨外周血内皮抑素含量水平与肿瘤的临床病理特征及预后的关系。
出处 《中华消化内镜杂志》 2006年第3期200-203,共4页 Chinese Journal of Digestive Endoscopy
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参考文献12

  • 1O'Reilly MS, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell, 1997,88:277-285.
  • 2Boehm T, Folkman J, Browder T, et al. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature, 1997,390:404-407.
  • 3Standker L, Schrader M, Kanse SM, et al. Isolation and characterization of the circulating form of human endostatin. FEBS Left, 1997,420 : 129-133.
  • 4Seetharam L , Gotoh N , Maru Y,et al. A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. Oncogene, 1995,10 : 135-147.
  • 5Kim YM, Hwang S, Kim YM, et al. Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1. J Biol Chem, 2002, 277:27872-27879.
  • 6Feldman AL, Alexander HR Jr, Bartlett DL,et al. A prospective analysis of plasma endostatin levels in colorectal cancer patients with liver metastases. Ann Surg Oncol,2001,8: 741 -745.
  • 7Feldman AL, Alexander HR Jr, Yang JC, et al. Prospective analysis of circulating endostatin levels in patients with renal cell carcinoma.Cancer,2002,95: 1637 - 1643.
  • 8John H, Preissner KT, Forssmann WG, et al. Novel glycosylated forms of human plasma endostatin and circulating endostatin-related fragments of collagen XV. Biochemistry, 1999,38 : 10217-10224.
  • 9Wen W, Moses MA, Wiederschain D, et al. The generation of endostatin is mediated by elastase. Cancer Res, 1999,59:6052-6056.
  • 10Fujisaki K, Mitsuyama K, Toyonaga A, et al. Circulating vascular endothelial growth factor in patients with colorectal cancer. Am J Gastroenterol, 1998,93:249-252.

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