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HIV感染者和AIDS患者淋巴细胞亚群异常表达及活化的研究

Studies on the abnormal expression and activation of peripheral lymphocyte subsets in HIV/AIDS patients
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摘要 目的 :了解HIV感染者和AIDS患者外周血淋巴细胞亚群及其活化后相关分子的表达。方法 :采用流式细胞仪检测了 10例HIV感染者、10例AIDS患者外周血中CD3+ 、CD4 + 、CD8+ 、CD8+ CD38+ 、CD4 5RO+ 、CD4 5RA+ 、CD6 2L+ 的表达及Th/Ts的改变。结果 :HIV(+)组与AIDS组的CD4 + T细胞比正常对照组显著下降 (P <0 0 1) ,CD8+ 明显增高 (P <0 0 1) ,Th/Ts明显倒置 ;HIV(+)组与AIDS组的CD8+ 、CD38+ 、CD4 5RO+ 较对照组明显增高 ,CD4 5RA+ 明显下降 (P <0 0 1) ;AIDS组的CD6 2L+ 较正常对照明显下降 (P <0 0 1)。结论 :人体感染HIV后一些免疫因素如低的幼稚T细胞数。 Objective:To investigate the expression of peripheral lymphocyte subsets and the relative molecules after activation in HIV/AIDS patients.Methods:The flow cytometry were used to detect CD3 +?CD4 +?CD8 +?CD8 +CD38 +?CD45RO +?CD45RA +?CD62L + in HIV/AIDS patients.Results:The HIV/AIDS patients had lower CD4 + and higher CD8 + than those of normal controls,Th/Ts was inverse significantly(P<0 01);Compared with normal controls CD8 +CD38 +?CD45RO + in HIV/AIDS patients markedly increased while CD45RA + decreased(P<0 01);CD62L + in AIDS patients reduced notably than that of healthy controls(P<0 01).Conclusion:Some immune factors such as lower naive T cell,excessive activation and apoptosis are involved in the pathogenesis of HIV.
作者 黄慧 陈升汶 李富荣 戴勇 王新根
机构地区 广东省深圳市人民医院(暨南大学医学院第二附属医院)
出处 《广西医学》 CAS 2002年第6期773-775,共3页 Guangxi Medical Journal
关键词 淋巴细胞亚群 活化 艾滋病 艾滋病毒 基因表达 HIV AIDS lymphocyte subset activation apoptosis
分类号 R512.91 [医药卫生—内科学]
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广西医学
2002年 第6期

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