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HIV感染者和AIDS患者淋巴细胞亚群异常表达及活化的研究

Studies on the abnormal expression and activation of peripheral lymphocyte subsets in HIV/AIDS patients
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摘要 目的　了解HIV感染者和AIDS患者外周血淋巴细胞亚群及其活化后相关分子的表达。方法　采用流式细胞仪检测 10例HIV感染者、10例AIDS患者外周血中CD3+ 、CD4 + 、CD8+ 、CD8+ CD38+ 、CD4 5RO+ 、CD4 5RA+ 、CD6 2L+ 的表达及Th/Ts改变。结果　HIV(+)组与AIDS组的CD4 + T细胞比正常对照组显著下降(P <0 .0 1) ,CD8+ 明显增高 (P <0 .0 1) ,Th/Ts明显倒置 ;HIV(+)组与AIDS组的CD8+ CD38+ 、CD4 5RO+ 较对照组明显增高 ,CD4 5RA+ 明显下降 (P <0 .0 1) ;AIDS组的CD6 2L+ 较正常对照组明显下降 (P <0 .0 1)。结论　人体感染HIV后一些免疫因素如低的幼稚T细胞数。 Objectives To investigate the expression of peripheral lymphocyte subsets and the relative molecules after activation in HIV/AIDS patients.Methods Using flow cytometry to detect CD3 +?CD4 +?CD8 +?CD8 +CD38 +?CD45RO +?CD45RA +?CD62L + in HIV/AIDS patients.Results The HIV/AIDS patients had lower CD4 + and higher CD8 + than those of normal controls,Th/Ts was inverse significantly(P<0.01),Compared with normal controls,CD8 +CD38 +?CD45RO + in HIV/AIDS patients markedly increased while CD45RA + decreased(P<0.01),CD62L + in AIDS patients reduced notably than that of healthy controls'(P<0.01).Conclusions Some immune factors,such as lower naive T cell,excessive activation and apoptosis are involved in the pathogenesis of HIV.
作者 黄慧 陈升汶 李富荣 戴勇 王新根
机构地区 广东省深圳市人民医院
出处 《宁夏医学杂志》 CAS 2002年第5期262-264,共3页 Ningxia Medical Journal
关键词 HIV AIDS 淋巴细胞亚群 HIV感染 细胞活化 细胞凋亡 HIV AIDS Lymphocyte subsets Activation
分类号 R512.91 [医药卫生—内科学]
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宁夏医学杂志
2002年 第5期

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