摘要
目的 :研究生长激素 (GH)对急性坏死性胰腺炎 (ANP)肠粘膜屏障损害的治疗作用。方法 :逆行胰胆管注射 3.5 %牛磺胆酸钠诱导ANP模型。试验分 4组 ,即正常 (N)组、假手术 (SO)组、坏死 (ANP)组和治疗(ANP +GH)组。术后 2 4小时抽血测血浆D 乳酸、血清GH、胰岛素样生长因子 (IGF 1)和白蛋白浓度 ,取末端回肠观察绒毛高度和粘膜厚度变化。结果 :ANP组回肠通透性上升 ,绒毛高度和粘膜厚度减小 ,血清白蛋白、GH和IGF 1均下降。GH治疗后ANP鼠肠粘膜病理变化减轻 ,肠道通透性降低 ,白蛋白和GH浓度提高 ,而对血清IGF 1影响不大。结论 :外源性GH可通过升高血清GH和白蛋白来减轻ANP时肠粘膜屏障的损伤。
Objective:To investigate the effect of growth hormone(GH) on gut barrier dysfunction in acute necrotizing pancreaitis(ANP) rats.Methods:ANP rats were induced by retrograde infusion of 3.5% sodium taurocholate into biliary pancreatic duct. The rats were divided into 4 groups: normal(N),sham operation(SO),ANP group and treatment(ANP+GH) group. 24 hours after operation,gut permeability was studied by level of plasma D lactate and histopathological alternation;serum GH,insulin like growth factor 1(IGF 1) and albumin were measured.Results:The gut permeability of ANP rats was increased together with decreased serum GH,IGF 1 and albumin;GH administration could relieve ANP gut histopathological changes,decrease plasma D lactate and increase serum GH and albumin level while there was no effect on serum IGF 1.Conclusion:Exogenous GH can cure ANP associated gut injury through increase of serum GH and albumin.
出处
《肝胆胰外科杂志》
CAS
2002年第1期23-25,共3页
Journal of Hepatopancreatobiliary Surgery
