摘要
目的 了解炎性细胞因子在急性胰腺炎发病机理及其并发器官功能障碍中的作用。方法 采用文献回顾方法对大量有关急性胰腺炎、细胞因子、临床资料和动物实验的有关文献进行综述。结果 急性胰腺炎时肿瘤坏死因子TNF α(tumornecrosisfactor α)和其他细胞因子水平明显升高 ,胰腺和肠道是主要的产生场所。它们的产生与动物模型的不同无关 ,抗细胞因子疗法可降低它们的水平。结论 炎性细胞因子在急性胰腺炎及其并发远离器官功能障碍中起着重要作用。
Objective To summarize the role of inflammatory cytokines in the pathogenesis of acute pancreatitis (AP) and gut barrier dysfunction in recent years. Methods Literatures on cytokines and experimental pancreatitis as well as clinical pancreatitis were collected and reviewed. Results Tumor necrosis factor-α and other inflammatory cytokines were elevated significantly during pancreatitis in many tissues, especially in pancreas and alimentary tract, in a fashion independent of the animal model used. Anti-cytokine therapy could decrease the concentration of the cytokines in experimental animal. Conclusion Inflammatory cytokines are believed to be primarily responsible for the pathogenesis of acute pancreatitis and its associated distant organ dysfunction. Further study of the nature of these cytokines may provide a new approach to treating this disease.
出处
《中国普外基础与临床杂志》
CAS
2000年第6期415-417,共3页
Chinese Journal of Bases and Clinics In General Surgery
