摘要
目的 探讨滴用丝裂霉素 C溶液治疗准分子激光屈光性角膜切削术 (excim erlaser photorefractive keratectom y,PRK)后角膜上皮下雾状混浊 (haze)的作用 ,并与地塞米松溶液对比。方法 对 4 1只新西兰白兔双眼行 PRK,术后分别给予 0 .2 g· L- 1丝裂霉素 C和 1.0 g· L- 1地塞米松滴眼治疗及平衡盐液滴眼作为对照 ,并行裂隙灯、角膜内皮镜、光镜、电镜检查。结果 术后 4、8周 ,丝裂霉素 C组与地塞米松组 haze程度相同 (P>0 .0 5 ) ,均较对照组为轻 (P<0 .0 5 )。光镜及电镜检查表明 :对照组术区角膜上皮细胞过度增生 ,前基质成纤维细胞增生活跃 ,纤维排列明显紊乱 ;而丝裂霉素 C组与地塞米松组角膜上皮细胞和前基质成纤维细胞的增生以及胶原纤维合成均受抑制 ,纤维排列较整齐。结论 丝裂霉素 C能减轻 PRK后 haze,且无明显副作用 ,可望成为防治
Objective To evaluate the ability of topical mitomycin C and dexamethasone to decrease haze after excimer laser photorefractive keratectomy(PRK).Methods Forty-one New Zealand rabbits underwent bilateral 193nm excimer laser myopic photorefractive keratectomy .All eyes were allocated randomly to be treated with 0.2 g·L -1 mitomycin C ,or 1.0 g·L -1 dexamethasone ,or a balanced salt solution as control ,after the operation. Slit-lamp ,specular microscope ,light microscope and transmission electronic microscope examinations were made. Results At 4 and 8 weeks, there were less haze in mitomycin C -treated and dexamethasone -treated animals than in the control group. Light microscope and transmission electronic microscope results showed that excessive epithelial hyperplasia and corneal fibroblast proliferation and subepithelial collagen proliferation were inhibited in mitomycin C -treated and dexamethasone -treated animals.Conclusion Mitomycin C can reduce corneal haze and hasn't visible toxicity on cornea.
出处
《眼科新进展》
CAS
2002年第2期88-90,共3页
Recent Advances in Ophthalmology
