摘要
目的观察羧基化氨基多糖药物抗胃溃疡的作用。方法选用酒精型、阿斯匹林型、盐酸型、醋酸型实验性胃溃疡和大鼠束缚、水浴应激性胃溃疡模型进行实验。结果对5种胃溃疡均有不同的抑制作用,大、中、小剂量组溃疡抑制率依次分别为:42.09%、35.55%、33.54%;53.65%、49.48%、46.76%;51.48%、44.09%、33.64%;49.44%、46.23%、45.10%和50.12%、44.63%、41.92%。结论羧基化氨基多糖具有预防和治疗胃溃疡的作用,其效应与德诺、法莫替丁和甲氰米胍相近。
Objective: To observe the effect of carboxyl-amino-polysaccharide on the gastric ulcer. Methods: Various rat models of gastric ulcer were established respectively by ethanol, aspirin, hydrochloric acid, acetic acid and bound stress in water bath. Results: Inhibitory rates of carboxyl polysaccharide in the dose of 0.5, 0.33, 0.17g/kg were 42.09%, 35.55%and 33.53%for the ethanol-induced model; 53.65%, 49.48%, and 49.76%for the aspirin-induced model; 51.48%, 44.09%, and 33.64%for the hydrochloric-acid-induced model, 49.44%, 46.23%, and 45.10%for the acetic-acid-induced model and 50.12%, 44.63%and 41.92%for the bound-stress-induced model respectively. Conclusion: Carboxyl-amino-polysaccharide can prevent and treat gastric ulcer. Its effect is similar to that of denol, famotidine and cimetidine.
出处
《中药新药与临床药理》
CAS
CSCD
2002年第3期158-160,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
羧基化氨基多糖
药理学
胃溃疡
中药疗法
动物疾病模型
Carboxyl-amino-polysaccharide/pharmacology
Gastric ulcer/TCD therapy
Disease models, animal
