摘要
【目的】探讨采用大剂量甲氨蝶呤 (MTX)预防性治疗中枢神经系统白血病 (CNSL)对急性淋巴细胞白血病(ALL)儿童智力与行为的影响。【方法】①按“中国 比内智力测验手册”方法对 4 2例ALL患儿在治疗前后与 4 0例正常儿童进行测试比较 ;②根据自制行为量表对ALL患儿治疗前后进行行为比较。【结果】①ALL患儿治疗前IQ、行为与对照组无差异 (P >0 0 5 ) ,而治疗后IQ明显低于对照组 ,(P <0 0 1) ;加用60 Co颅脑放疗组IQ降低更为明显。②ALL患儿治疗后行为问题出现率明显高于对照组 (P <0 0 1)。【结论】大剂量MTX治疗对ALL儿童的智力与行为有不同程度的损害作用 ,加用60
To evaluate the effects of high dose methotrexate for central nervous system leukemia prophylaxis on intelligence and behavior functions of children with acute lymphoblastic leukemia (ALL) Group A included 33 ALL Patients treated only with methotrexate Group B included 9 ALL Patients treated with combination of methotrexate and 60 Co cranial irradiation The control group (group C) included 40 healthy children which shared the same education and environmental background with the patients above Each patient before and after 2 years treatment, and subject of the control group were evaluated respectively with Chinese revisions of Binet measures of intelligence quotient ①The IQ of both group A and group B after treatment were significantly lower than that of the control group(P<0 01) The IQ of group B after treatment decreased more significantly ②The incidence of behavioral problems of ALL patients after treatment was higher than that of the control group [Conclusion] Intelligence and behavior functions of patients with ALL after treatment with high dose methotrexate are impaired 60 Co cranial irradiation may aggravate the impairment
出处
《中山医科大学学报》
CSCD
北大核心
2002年第3期208-210,共3页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
中山医科大学行为医学中心CMB基金资助项目 (97)
