摘要
报告２０５例小儿急性淋巴细胞白血病（ＡＬＬ），诱导缓解期采用强烈ＣＯＤＰ＋Ｌ－ＡＳＰ和ＣＯＡＰ＋Ｌ－ＡＳＰ方案，联合大剂量氨甲喋呤（ＨＤ－ＭＴＸ）及头颅放疗（１８Ｇｙ）进行庇护所预防。使５年无病生存率（ＥＦＳ）达到７４．４％，中枢神经系统白血病复发率降至１．５％，睾丸白血病复发率降至３．４％。治疗效果表明：早期强烈化疗及有效的庇护所预防是减少骨髓及髓外复发，提高ＥＦＳ的关键。
he clinical therapeutic results in 205 children withacute lymphoblastic leukemia were analysed retrospecti-vely. Five-years event-free survival (EFS) of the newlydiagnosed patients received remission intensifiedchemotherapy (CODP or COAP regimen),followinggiven high dose methotrexate (HD-MTX) and then18Gy cranial irradiation,was 74. 4 % overall.The CNSand testicular relapse rates were significantly decreasedto 1.5% and 3. 4% respectively.These results showedthat the intensified induction chemotherapy and effectiveshelter prophylaxis were the key to elevate the EFS anddecrease the relapse.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1994年第5期248-250,共3页
Chinese Journal of Hematology
关键词
白血病
治疗
儿童
ALL
疗效
Acute lymphoblastic leukemia Shel-ter prophylaxis Event-free survival
