摘要
目的 旨在研究过氧化物酶增殖物活化受体 γ2 (PPARγ2 )基因 Pro12 Ala多态性与 2型糖尿病相关性。方法 选取北京地区汉族 10 1对病例 -对照配偶对 ,应用聚合酶链反应 -长度多态性方法进行基因型测定。结果 对照组中携带 Ala12等位基因组 ,血清载脂蛋白 B明显低于 Pro12 Pro基因型组 (P =0 .0 0 6 ) ;但 Pro12 Ala多态性与 2型糖尿病不相关 (OR=1.4 8,95 % CI=0 .5 2～ 4 .18,P =0 .4 6 1)。结论 在北京汉族人群中 ,PPARγ2基因 Pro12 Ala多态性与脂肪代谢异常有关 ,PPARγ2基因多态性可能不是
Objective To study the association of peroxisome proliferator activated receptorγ2 (PPARγ2) gene polymorphism with type 2 diabetes mellitus.Methods PPARγ2 gene Pro12Ala polymorphism was examined using polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) in 101 couples of type 2 diabetes mellitus normal control.Results In control group, heterozygosity carriers had lower serum apolipoprotein B (P=0 006).The Pro12Ala polymorphism in PPARγ2 gene is not associated with type 2 diabetes mellitus(OR=1.48,95%CI=0.52～4.18,P=0.461).Conclusion PPARγ2 gene Pro12Ala polymorphism is associated with abnormal lipid metabolism; PPARγ2 gene may not play a critical role in the development of type 2 diabetes mellitus in Han of Beijing Chinese.
出处
《中国糖尿病杂志》
CAS
CSCD
2002年第2期74-76,共3页
Chinese Journal of Diabetes
