摘要
为探讨 p5 3、 c- erb B- 2蛋白表达与食管鳞癌生物学行为的关系 ,应用免疫组化 L SAB法研究 181例食管鳞癌中p5 3、 c- erb B- 2蛋白的表达。结果发现 ,正常食管粘膜均无 p5 3、c- erb B- 2蛋白的表达。 47%食管鳞癌出现 p5 3表达 ,p5 3阳性病例癌旁非典型增生上皮出现 p5 3表达 ,p5 3阴性病例癌旁非典型增生上皮亦为阴性。p5 3阳性表达率与患者年龄、性别、肿瘤大小、组织学分级 ,临床 TNM分期无关 ,且与预后无关。 5 1.4%食管鳞癌呈现 c- erb B- 2蛋白表达 ,癌旁非典型增生上皮无 c- erb B- 2表达。c- erb B- 2阳性率与肿瘤组织学分级、浸润深度、淋巴结转移及肝转移有关 ,c- erb B- 2阳性表达者预后较差。结果提示 ,p5 3表达在食管鳞癌发生中起重要作用 ;c- erb B- 2表达在食管鳞癌浸润转移中起重要作用。同时进行 p5 3、 c-erb B- 2蛋白免疫组化检测 ,有助于对食管鳞癌进行早期诊断 ,监测病情和判断预后。
This paper aims at studying the relationship between the expression of p53 and c erbB 2 protein and biologic behaviors of squamous cell carcinoma of esophagus. Using immunohistochemical LASB technic, the p53 and c erbB 2 protein were examined in 181 cases of squamous cell carcinoma of esophagus. p53 was positively stained in 47% of the tumours. p53 protein were observed in the foci of dysplasia of p53 expression case. No immunoreactivity were observed in the foci of dysplasia of p53 disexpression case. p53 expression did not correlate with sex, age, tumor size, histological grade, TNM classification and prognosis. c erbB 2 protein was found positive in 51 4% of the tumors in this series. c erbB 2 expression was related to histological grade, the depth of invasion, lymphnode metastasis and hepatic metastasis. Patient with c erbB 2 positive tumor had lower survival rate. The results suggest that p53 expression may be the essential impression in the carcinogenesis and the development of squamous cell carcinom of esophagus, c erbB 2 expression may be beneficial in the invasion and metastasis of squamous cell carcinoma of esophagus. Combined assay of p53 and c erbB 2 protein might be useful in determining early diagnosis, Observing patient's progression and evaluating prognosis of squamous cell carcinoma of esophagus.\;
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2000年第2期175-177,共3页
Chinese Journal of Histochemistry and Cytochemistry
