摘要
目的:探讨骨桥蛋白(OPN)作为胃癌肿瘤标志物的价值,并与CEA、CA19-9进行比较。方法:应用酶联免疫吸附试验法(ELISA)检测66例胃癌患者的外周血(OPN)、CEA、CA19-9的浓度,结合临床特征进行分析。结果:胃癌患者OPN、CEA、CA19-9检测的敏感性分别为78.8%、34.8%、42.4%,特异性分别为95.0%、90.0%、80.0%。三种标志物联合检测,其敏感性为87.8%。OPN、CEA、CA19-9浓度与胃癌临床分期、最大直径、淋巴结转移程度及有无远处转移有关,手术前后三种标志物浓度具有显著性差异。结论:骨桥蛋白是胃癌的一种较理想的肿瘤标志物,三者联合检测能够用于胃癌的诊断和预后评估,监测病情的进展。
Objective:To evaluate the significance of osteopontin as a tumor marker and compare with carcinoembryonic antigen and carbohydrate antigen19-9in gastric cancer.Meth-ods :Plasma level of osteopontin,carcinoembryonic antigen and carbohydrate antigen19-9were detected in66patients with gastric cancer by ELISA method.The relationship between the level of osteopontin,carcinoembryonic antigen,carbohydrate antigen19-9and the clinical features of gas-tric cancer were analyzed.Results:The sensitivity of osteopontin,carcinoembryonic antigen,car-bohydrate antigen19-9was78.8%?34.8%?42.4%and the specifity of the three markers is95%?90%?80%respectively.The sensitivity of combined detection of three markers is87.8%.Levels of osteopontin,carcinoembryonic antigen,carbohydrate antigen19-9were related with TNM stage,maximum diameter,degree of lymphnode metastasis,metastasis in gastric cancer.Pre-and postop-erative levles of the three markers were obviously different.Conclusion:Osteopontin was one of the ideal tumor markers and it could be used in diagnosis,prognois evaluation,monitoring for gastric cancer combined with carcinoembryonic antigen,carbohydrate antigen 19-9.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2002年第12期881-884,共4页
Chinese Journal of Clinical Oncology
关键词
胃癌
外周血
骨桥蛋白
检测
癌胚抗原
CA19-9
Gastric neoplasm Osteopontin Carcinoembryonic antigen Carbohydrate antigen 19-9 Plasma
