摘要
目的 探讨氟西汀联合小剂量阿米替林治疗抑郁症的疗效。方法 将我院 18～ 6 5岁符合CCMD - 2 -R抑郁症诊断标准的 43例患者 ,随机分为两组。研究组 2 2例 ,采用氟西汀 2 0mg+阿米替林 5 0～ 10 0mg (平均 77 5mg d)进行治疗 ;对照组 2 1例 ,单用氟西汀治疗 ,2 0mg d ,疗程均为 6周。用汉密顿抑郁量表 (HAMD)和汉密顿焦虑量表(HAMA)进行症状评分 ,根据减分率判断疗效 ,用副反应症状量表 (TESS)评价两组的副作用。结果 HAMD减分率两组间比较自第 2周末始差别有显著性意义 (P <0 0 5 ) ;HAMA减分率两组间比较 ,自第 1周末始差别即有显著性意义 (P <0 0 1) ;TESS评分两组间差别亦有显著性意义 (P <0 0 5 ) ,但未见严重副反应。结论 氟西汀联合小剂量阿米替林治疗抑郁症效果优于单用氟西汀。
Objective To investigate the feasibility and efficacy of Fluoxetine with Amitriptyline in treating depression patients.Methods A total of 43 patients who were in line with the CCMD-2R criteria of depression were randomly divided into two groups.22 patients of study group were treated with Fluoxetine(20mg/day) and Amitriptyline(50～100mg/day).21 patients of control study were treated with Fluoxetine(20mg/day) only.The efficacies were assessed by HAMA and HAMD,and the side effects were assessed by TESS.Results The decreased rate of HAMD in study group was significantly higher than that in control group at the end of 2 weeks(P<0.05).The decreased rate of HAMA in study group was also significantly higher than that in control group at the end of 1 week(P<0.01).Conclusion The efficacy of using Fluoxetine with Amitriptyline to treat depression is better than that of using Fluoxetine only.
出处
《中国全科医学》
CAS
CSCD
2002年第4期272-273,共2页
Chinese General Practice
