摘要
目的 :比较每周 1次与每天 1次氟西汀维持治疗广泛性焦虑症的临床疗效。 方法 :将 6 4例已接受每天 1次氟西汀治疗 ,且临床疗效已达显著进步或痊愈的广泛性焦虑症病人 ,随机分为研究组(31例 )和对照组 (33例 ) ,研究组前 2周改为每周 2次氟西汀治疗 ,第 3周开始改为每周 1次氟西汀治疗 ;对照组继续每天 1次氟西汀治疗 ,疗程 3个月。采用汉密尔顿焦虑量表 (HAMA )和副反应症状量表(TESS)评定疗效和药物不良反应。 结果 :研究组仅 1例失败而更改治疗方案 ,研究组与对照组维持治疗前后组内和组间 HAMA评分比较都无显著差异。 结论 :经过急性期治疗临床症状已经好转的广泛性焦虑症病人 ,采用氟西汀每周 1次的治疗方案 。
Objective:To compare the efficacy of daily dosing and once weekly dosing of fluoxetine in the maintenance treatment of generalized anxiety disorder (GAD). Method:After being treated initially with daily doses of fluoxetine and having been improved,64 patients with GAD were randomly assigned to study group ( n =31) and control group ( n =33) for three months.The study group switched to twice weekly dosing in the first and second week,and switched to once weekly dosing from the third week.The control group continued daily dosing regimen.Assessment scales included Hamilton rating scale for anxiety (HAMA),and treatment emergent symptom scale (TESS). Results:All but one patient of the study group successfully switched to once weekly dosing.There were no significant differences in HAMA scores in two groups before and after the maintenance treatment. There was no significant difference in the reduction of HAMA scores between the two groups. Conclusion:It is suggested that once weekly fluoxetine dosing is effective in the maintenance treatment of GAD.
出处
《临床精神医学杂志》
2002年第2期82-83,共2页
Journal of Clinical Psychiatry
