摘要
目的 比较帕罗西汀和氟西汀治疗伴焦虑症状的抑郁症的临床疗效及副反应。方法 符合CCMD - 3抑郁症的诊断标准 ,并且汉密尔顿焦虑量表评分 >14分的门诊及住院患者 5 8例 ,随机分为两组 ,为期 6周的治疗 ,于治疗前及治疗后第 1、2、4、6周末用汉密尔顿抑郁量表 (HAMD)、汉密尔顿焦虑量表 (HAMA)评定疗效 ,以不良反应症状量表 (TESS)观察副作用。结果 帕罗西汀和氟西汀治疗伴焦虑症状的抑郁症的显效率分别为 85 19%和 81 4 8% ,无显著差异。两组的HAMD减分率亦相当 (P >0 0 5 )。两组的HAMA减分率有显著差异 (P <0 0 5 )。两组的副反应相当 ,且均较轻。结论 帕罗西汀和氟西汀对伴焦虑症状的抑郁症的疗效均显著 ,抗抑郁效果两药相当 ,抗焦虑效果前者优于后者。两者副反应均较轻。
Objective Comparing the clinic curative effect and side-effect of curing depression associated with anxiety in paroxitine Vs fluoxetine.Method Measuring up the diagnosis of CCMD-3,and using HAMA to mark 58 cases of clinic and in-patient which is over 14,then dividing into 2 teams at random,having a 6-week therapy,and taking use of HAMD and HAMA to evaluate the curing effect before treating and 1,2,4,6 week after treating,observing the side-effect in TESS.Result Effective rate respectively 85 19% and 81 48% of curing worrying-depressed symptom in paroxitine Vs fluoxetine,no markedly difference.HAMD subtraction mark rate of two teams equivalent (P>0 05).HAMA subtraction mark rate of two teams remarkably different (P<0.05).The side effect of two methods equivalent,both comparatively light.Conclusion When depression associated with anxiety in paroxitine Vs fluoxetine,both having remarkable curative effect,equivalent effect of anti-depression,but on anti-worrying,the first better than the latter,both having light side-effect.
出处
《四川精神卫生》
2004年第4期210-212,共3页
Sichuan Mental Health
