摘要
目的:探讨尿型纤溶酶受体(UPAR)和血管内皮生长因子(VEGF)在肝细胞肝癌(HCC)的表达与其病理学特性和肿瘤浸润转移的关系。 方法:采用抗受体抗体SABC免疫组织化学染色检测79例肝细胞肝癌标本中UPAR表达,以常规SABC免疫组化方法检测VEGF的表达。 结果:在79例HCC中,UPAR的表达阳性率为51.9％(41/79),VEGF的表达阳性率为46.8％(37/79),二者表达与肝癌大小、分化程度无关,但与肿瘤的转移显著相关。 结论:UPAR和VEGF的表达可作为HCC的侵袭表型,可作为估计预后的指标,肝细胞肝癌中VEGF的表达与UPAR表达具有较高的相关性。
AIM: To investigate the relationship of the expression of urokinase type plasminogen activator receptor (UPAR) and vascular endothelial growth factor (VEGF) with invasion and metastasis of human hepatocellular carcinoma (HCC).METHODS: Expression of UPAR and VEGF was detected in paraffin-embedded tissues by immunohistochemical SABC technique in 79 cases of HCC.RESULTS:The positive rates of UPAR and VEGF were 51.9% (41/79) and 46.8 %(37/79) respectively in 79 cases of HCC. Both UPAR and VEGF were significantly related to metastasis, but there was no significant correlation between the differentiation and tumor size of HCC.CONCLUSION: Expression of UPAR and VEGF may be signs of aggressive phenotype of the tumor, which can be used as a valuable parameter to evaluate prognosis of patients with HCC. UPAR expression is significantly correlated with that of VEGF.
出处
《世界华人消化杂志》
CAS
2002年第4期381-383,共3页
World Chinese Journal of Digestology
