摘要
目的 检测CD44V8-10在胃癌中的表达,探讨其与胃癌临床病理特征之间的关系及意义.方法 用SP免疫组化方法检测CD44V8-10在63例胃癌中的表达,比较不同分化程度、是否转移、浸润深度及肿瘤部位阳性表达率的不同,探讨其间的关系.结果63例胃癌CD44V8-10阳性表达率为49.2%,高低分化腺癌阳性表达率分别为68.0%和36.8%(P<0.05),有无淋巴结转移的阳性表达率分别为54.4%和25.0%(P<0.05),有无远处转移的阳性表达率分别为76.9%和42.0O(P<0.05),浸润超过浆膜和未超过浆膜阳性表达率分别为55.0%和46.8%(P>0.05),贲门部癌和胃体、胃窦部癌阳性表达率分别为66.7%和45.1%(P>0.05).结论CD44V8-10阳性表达与胃癌分化程度、淋巴结转移及远处转移有关,与胃癌部位.浸润程度无关,并可能对高危预后病人的判断有一定价值.
Objective : To evaluated the siginificance of expression of CD44 variant exons 8-10 (cd44v8-10) in gastric cancer. Methods :The expression of CD44V8-10 was examined on 63 cases of gastric cancer with Spimmunohistochemical technique. The relationship among expression of CD44V8-10 and grade, metastasis, infiltration and site of each tumor was noticed. Results :The expression of CD44V8-10 was 49.2% in 63 cases of gastric cancer. The expression rates were 68.0% and 36.896 (P< 0.05) in high and low differentiated adenocarcinoma, 54. 4% and 25.0% (P<0.05) in cases with and without lymph metastasis respectively, 76.9% and 42.0% (P<0.05) in patients with and without distal metastasis, 55. 0% and 46.8% (P>0.05) in tumors with and without serosa involved, 66.7% and 45. 1% (P>0.05) in gastric cancer located in cardiac and stomach body respectively. Conclusion :CD44V8-10 may playa certain role in the metastasis of gastric cancer, and CD44V8-10 expression may be of some value in identifying subgroups of patients who may be at higher risk.
出处
《中国现代普通外科进展》
CAS
1999年第2期23-24,共2页
Chinese Journal of Current Advances in General Surgery
