摘要
目的：评价吲哒帕胺缓释片（１．５ｍｇ）治疗轻、中度高血压病的临床疗效及其延迟的长时效应。方法：按照ＷＨＯ／ＩＳＨ的诊断标准，筛选出３０例轻、中度原发性高血压患者，男１２例，女１８例，平均年龄５２．７±１１．０岁。经过２周的安慰剂洗脱期进人８周的吲哒帕胺缓释片（１．５ｍｇ）的开放治疗期。于服安慰剂期末及治疗２，４，６，８周末测坐位收缩压、舒张压及心率，并采用动态血压监测方法对患者行服安慰剂期末及治疗８周末３０ｈ动态血压监测（ＡＢＰＭ）。结果：经过８周治疗后，平均坐位收缩压／舒张压下降（２３．４± １５．５／９．５ ±７．７） ｍｍＨｇ，治疗２周即达统计学意义，Ｐ＜０．０００１并持续到８周。３０ｈＡＢＰＭ与治疗前比较显示，平均收缩压／舒张压；前２４ｈ及２５～３０ｈ较治疗前明显下降，分别 １３．２／６．４ ｍｍＨｇ和 １２．１／５．０ ｍｍＨｇ，具有统计学显著性。结论：吲哒帕胺缓释片是一类利尿扩血管降压药物，每日一次用药能有效控制３０ｈ的血压。
OBJECTIVE: To evaluate the efficacy and the delayed and long time effect of indapainide 1.5mg sustained-release with mild to moderate essential hypertension. Methods: According WHO/ISH, 30 patients with mild to moderate essential hypertension were studied, twelve was male, and eighteen was female. A 2-week placebo washout period was followed by an 8-week open treatment period of indapamide 1.5mg sustained-release. At the end of placebo mn-in and 2,4,6,8 weeks after treatment, systolic blood pressure, diastolic blood pressure and heart rate were measured. At the end of placebo run-in and 8 weeks after treatment, 30-hour ambulatory blood pressure monitoring were recorded. Results: After 8-weeks open treatment, mean sitting systolic blood pressure(SBP)/ diastolic blood pressure(DBP) decreased significantly (23.4 ±15.5/9.5 ±7.7)mmHg, P < 0.001 .The significant antihypertensive effect was seen after 2 weeks of therapy and continued throughout the 8 weeks. In the 30-hour ambulatory blood pressure monitoring with treatment before ,mean SBP/DBP; 24-hour and 25-30-hour all reduced significantly compared with baseline values,( 13.2/6.4 nimHg and 12. 1/5.0 mmHg). Conclusion: Indapamide 1.5mg sustained-release is effective antihypertensive with diuretic and vasodilating activity on mild to moderate essential hypertension. Blood pressure can be controlled in 30 hours administered orally once daily.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2002年第1期46-48,共3页
The Chinese Journal of Clinical Pharmacology
关键词
高血压
动态血压监测
吲哒帕胺缓释片
hypertension
ambulatory blood pressure monitoring
indapamide sustained-release
