摘要
目的评价北京降压0号治疗轻中度原发性高血压患者的降压疗效,并与氢氯噻嗪单药疗效进行比较。方法将57例原发性高血压患者随机分为2组,分别应用北京降压0号和氢氯噻嗪治疗8周。应用动态血压监测(ABPM),治疗前后测定动态血压、诊室血压、心率及相关血清生化指标。结果治疗8周后,2组的诊室血压、24 h动态血压、收缩压负荷及舒张压负荷均较治疗前明显降低,差异均有统计学意义(P<0.01),心率较治疗前无明显变化。降压幅度比较,北京降压0号降低舒张压的幅度显著高于氢氯噻嗪(P≤0.01),降低收缩压幅度2组无明显差异。北京降压0号组和氢氯噻嗪组总有效率分别为79.3%和42.9%(P=0.005)。北京降压0号组收缩压和舒张压的谷峰比分别为60.59%和78.13%,平滑指数(SI)分别为0.72±0.27和1.09±0.26。氢氯噻嗪组收缩压和舒张压的谷峰比分别为39.76%和30.79%;SI分别为0.59±0.29和0.40±0.26。2组出现的不良反应均轻微。结论北京降压0号是一种安全有效的复方降压制剂,其降压疗效优于氢氯噻嗪单药应用。
Objective To compare the antihypertensive efficacies between of Beijing hypotensive No. 0 and hydrochlorothiazide （HCTZ） with ambulatory blood pressure monitoring. Methods 57 patients with mild to moderate essential hypertension were divided into two groups randomly. These patients were treated with Beijing hypotensive No. 0 or HCTZ for 8 weeks. Clinic blood pressure （CBP）, 24 h ambulatory blood pressure, heart rate and correlative serum biochemics were examined before and after 8 weeks＇ treatment. Results After treatment, clinic blood pressure and 24 h ambulatory blood pressure decreased significantly compared with baseline in two groups. No significant difference was found in heart rate. DBP decreased more in Beijing hypotensive No. 0 group than HCTZ group （P≤0.01）. The total efficacy rates were 79.3% and 42.9% respectively in Beijing hypotensive No. 0 group and HCTZ group （P=0. 005）. The trough to peak ratios for SBP and DBP were 60. 59% and 78. 13%, and smoothness index were 0. 72±0.27 and 1.09±0.26 respectively in Beijing hypotensive No. 0 group, while those of HCTZ were 39.76% and 30.79%, and smoothness index were 0.59±0. 29 and 0.40±0.26 respectively. The adverse reactions in two groups were mild. Conclusion Beijing hypotensive No. 0 is an efficacy and safe compound antihypertensive drug, which has better antihypertensive effects than that of HCTZ monotherapy.
出处
《首都医科大学学报》
CAS
2006年第2期222-225,共4页
Journal of Capital Medical University
关键词
北京降压0号
氢氯噻嗪
高血压
动态血压
Beijing hypotensive No. 0
hydrochlorothiazide
hypertension
ambulatory blood pressure
