摘要
目的 :探讨妊高征患者应用钙剂预防或治疗时ET水平的变化。以及对妊高征病情的影响。方法 :选择100例妊娠24～26周预测妊高征试验阳性的孕妇。首次测量血清钙平均(2 20±0 3)mmol/L、血清内皮素 (ET)平均 (58 06±9 78)ng/L、平均动脉压(12 5±0 3)kpa。随机分为两组。50例口服葡萄糖酸钙片1～2g/日 ,治疗的病人为观察组 ;50例未口服葡萄糖钙片治疗的病人为对照组。12周后复查血清钙、血清ET、平均动脉压。结果 :观察100例预测妊高征阳性的病人 ,12周以后妊娠达36～38周。观察组和对照组的血清钙 (2 20±0 2)、(1 97±0 3)mmol/L、血清ET(61 76±18 6)、(132±705 64)ng/L、平均动脉压(12 7±0 3)、(13 6±0 3)kpa。两组比较差异有显著性P<0 05。结论 :血清钙与血清ET平均动脉压之间成负相关系。妊高征患者应用钙剂可达到预防和治疗的作用 。
Objective:To study the variation of the level of Endothelin in the patients with toxemia of pregnancy prevented and treated with Calcium.Methods:100 pravidas for 24～26 gestational weeks with the positive reaction of toxemia of pregnancy were selected and divided into two groups in randomly.The first serum Calcium was examined,its average was (2.20±0.3)mmol/L,the averge of serum endothelin was (58.06±9.78)ng/L,the average of artery pressure was (12.5±0.3)kpa.50 cases in the observation group were given oral Calcium Gluconate 1～2g/day,the others in the control group were not given oral Calcium Gluconate.The serum Calcium?serum endothelin and average artery pressure were reexamined after 12 weeks.Results:The pravidas had attained to 36～38 gestational weeks after 12 weeks.The serum Calcium in the observation group was (2.20±0.2)mmol/L and that in the control group was (1.97±0.3)mmol/L.the serum endothelin in the observation group was (61.36±18.6)ng/L and that in control group was (132±705.64)ng/L.the average artery pressure in the observation group was (12.7±0.3)kpa and that in control group was (13.6±0.3)kpa.There was signifficant difference between two groups(P<0.05).Conclusion:The serum Calcium is negative correlate with the serum endothelin and average artery pressure.Using Calcium in the toxemia of pregnancy has an impartant role of prevention and treatment,which has a signifficant effect for the condition in patients with toxemia of pregnancy.
出处
《现代医药卫生》
2002年第4期273-274,共2页
Journal of Modern Medicine & Health
