期刊文献+

小孔硅胶涂敷纤维素三肉桂酸酯手性固定相的制备及应用

Preparation and Application of Cellulose Tris-cinnamate Coated Chiral Stationary Phases with Small-pore Silica Supports
在线阅读 下载PDF
导出
摘要 由纤维素和肉桂酰氯反应得纤维素三肉桂酸酯,涂敷于几种小孔硅胶载体上制得手性固定相,将自制手性固定相应用于二氢菲二醇、联萘酚醚衍生物、氢化安息香等的拆分,探讨了载体种类、流动相组成、柱温等对手性拆分的影响。二氢菲二醇、联萘酚醚衍生物获得了优良的拆分,分离度可达8.62和7.71。该法简单易行、成本低,可应用于相关化合物对映体纯度的测定。 Cellulose tris-cinnamate was prepared from cellulose and cinnamonyl chloride. Then the product was coated on several small-pore silica supports. The obtained chiral stationary phases were applied to separate the enantiomers of some compounds including trans-9,10-dihydrophenanthrene-9,10-diol,1,1′-binaphthyl-2,2′-O,O′-methylene and hydro- benzoin. The effects of silica support,mobile phase composition and column temperature on the enantioseparation were studied. Trans-9,10-dihydrophenanthrene-9,10-diol and 1,1′-binaphthyl-2,2′-O,O′-methylene achieved favorable en- antioseparation,and the resolution could reach 8.62 and 7.71,respectively. The method was simple and low-cost,and can be used to determine the enantiomeric purity of corresponding compounds.
作者 刘国庆 Liu Guo-qing(Hydrology and Water Resources Reconnaissance Survey Substation of Xiamen,Xiamen,Fujian 361011,China)
出处 《福建分析测试》 CAS 2018年第5期34-38,共5页 Fujian Analysis & Testing
基金 福建省质量技术监督局项目(fjqi2013109)资助
关键词 纤维素三肉桂酸酯 手性固定相 手性拆分 小孔硅胶 Cellulose tris-cinnamate Chiral stationary phase Enantioseparation Small-pore silica
  • 相关文献

参考文献1

二级参考文献7

  • 1Zhang Q,Chirality,2000年,12卷,714页
  • 2Zhang Q,J Chromatogr A,2000年,866卷,173页
  • 3张强,中国专利 :991130 91 X,1999年
  • 4Yang J,J Chromatogr,1993年,645卷,241页
  • 5He X M,Nature,1992年,358卷,209页
  • 6Zhang Q,Chromatogr
  • 7黄天宝,吴邦桂,龙远德,旷昌渝,周竞先.β-环糊精键合固定相的制备和评价[J].分析化学,1991,19(11):1257-1260. 被引量:9

共引文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部