摘要
目的 :探讨Fas/FasL在肺癌中的表达及意义。方法 :采用免疫组化方法检测 42例非小细胞肺癌组织的Fas/FasL表达。结果 :2 2例Fas表达阳性 ,表达率 5 2 .3%(2 2 / 42 ) ,2 4例FasL表达阳性 ,表达率 5 7.1%(2 4/42 ) ,二者表达无相关性 ;鳞癌和腺癌的Fas/FasL表达无差异 ;TNM分期与FasL表达显著正相关 (P <0 .0 5 ) ,而与Fas表达无显著性相关 (P >0 .0 5 )。结论 :Fas/FasL在肺癌细胞逃避机体免疫方面起重要作用 ,FasL在肺癌转移机制中的作用值得进一步研究。
Purpose:To study the expression and significance of Fas/FasL in lung cancer.Methods:The expression of Fas/FasL was detected in 42 cases of non-small-cell lung cancer by immunohistochemistry. Results:Out of 42 cases, Fas was positive in 22 cases (52.3%) and FasL was positive in 24 cases(57.1%), there was no correlation between the expression of Fas and FasL. The expression of Fas/FasL was not different in squamous cell carcinoma and adenocarcinoma. The stage of lung cancer had a positive correlation with the expression of FasL, while was no correlation with Fas expression.Conclusions:The expression of Fas/FasL in lung cancer may play an important role in the escape of tumor cells from immune function and FasL is worthy of further research in metastasis of lung neoplasms.
出处
《中国癌症杂志》
CAS
CSCD
2002年第1期29-30,共2页
China Oncology
基金
浙江省教委基金项目 (No .98114 8)
