摘要
目的 :通过对济南铁路地区 6 0岁以上老年人进行痴呆的流行病学调查 ,进一步探讨老年期痴呆的患病率及Alzheimer病 (AD)的有关危险因素。方法 :用简易精神量表 (MMSE)进行初选 ,根据DSM -IV -R (1994 )痴呆标准、NINCDS -ADRDA的AD临床诊断标准及NINCDS -AIREN血管性痴呆 (VD)的诊断标准和Hachinski (HIS)缺血指数量表、头颅CT、MRI和实验室基因学等检查 ,综合诊断痴呆并进一步区分AD和VD。结果 :老年期痴呆总患病率为 4 17% ,AD和VD的患病率分别为 2 83%和 1 34% ,其中AD占 6 7 8%。结论 :高龄、文化程度低是AD的易患因素 ,高糖饮食可能为AD的诱因之一 ,少量吸烟可能会降低AD的患病率 ,脑电图、FT3、头颅CT、MRI有助于诊断和分期。
Objective:To study the association of Alzheimer's disease (AD)with some factors and to find the risk factors,by an epidemiological study on senile dementia in Jinan Railway Area.Methods:Senile dementia was diagnosed according to MMSE,classified to AD and VD according to DSM-IV-R、NINC DS-ADRDA、NINCDS-AIREN、Hachinski score、CT and MRI,as well as the laboratory test of gene.Results:The morbidity of senile dementia was 4.17%,and 2.83% of AD,1.34% of VD.Conclusion:Elderly population and lower education seemed be more susceptible to AD.High sugar diet may be a risk factor.Light smoking may reduce the morbidity of AD.EEG、FT3、CT and MRI can be helpful for diagnosis.
基金
济南铁路局自然科学基金资助课题
关键词
痴呆
老年人
流行病学
病因
Dementia
Elderly population
Epidemiology
Pathogeny
