摘要
目的观察盐酸多奈哌齐联合盐酸美金刚治疗阿尔茨海默病(AD)的临床效果。方法选取医院收治的AD患者96例,随机分为观察组和对照组,每组48例。对照组给予盐酸多奈哌齐治疗,观察组在此基础上联合使用盐酸美金刚治疗,观察2组临床疗效及简易精神量表(MMSE)、日常生活能力评分表(ADL)、AD病理行为量表(BEHAVE-AD)评分结果,观察不良反应发生情况。结果观察组总有效率为83.33%,高于对照组的64.58%(P<0.05)。治疗后2组MMSE、ADL评分较治疗前均明显升高,BEHAVE-AD评分明显下降,差异均有统计学意义(P<0.01);观察组各项评分改善程度均优于对照组(P<0.01)。观察组不良反应发生率为10.42%,对照组为8.33%,差异无统计学意义(P>0.05)。结论盐酸多奈哌齐联合盐酸美金刚能明显改善AD患者痴呆症状,疗效显著,安全性较高,值得临床推广应用。
Objective To observe the combination of donepezil hydrochloride and memantine hydrochloride in the treatment of Alzheimer＇s disease （AD）. Methods 95 patients with AD were randomly divided into control group and observation group with each group of 48 cases. The patients in control group were treated with donepezil hydrochloride and patients in observation group were served with the combination of donepezil hydrochloride and memantine hydrochloride. The results of scoring clinical effect, Mini-Mental State Examination （ MMSE）, Activities of Daily Living （ADL） and AD Histopathological Behavior Scale （BEHAVE-AD） for the two group were observed and the adverse events were to be observed as well. Results The total efficiency rate of the observation group was 83.33%, which was higher than that of the control group of 64.58% （P 〈 0.05）. After treatment, MMSE and ADL scores of the two groups were significantly higher than those before treatment, while BEHAVE-AD score decreased significantly. The difference was statistically significant （P 〈 0. 01 ）. The scores of all tes- ting indicators in the observation group outperformed those of the control group （P 〈 0.01 ）. The incidence of adverse reactions was 10.42% for observation group and 8.33% for the control group with no statistically significant difference （ P 〉 0.05 ）. Conclusion Donepezil hydrochloride combined with memantine hydrochloride can effectively and safely treats symptoms of dementia, hence it is worth of clinical application and promotion.
出处
《临床合理用药杂志》
2017年第8期1-2,14,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
盐酸多奈哌齐
盐酸美金刚
阿尔茨海默病
Donepezil hydrochloride
Memantine hydrochloride
Alzheimer＇s disease
