摘要
目的 食管癌腔内放射治疗与单纯外照射的疗效分析 ,探讨食管癌腔内高剂量率、时间、剂量、分割因素 ,提高局部控制率和生存率。方法 对 2 0 0例食管癌患者随机分为腔内加体外照射A、B两组 ,各 6 0例 ,单纯外照射C组 80例 ,治疗方法 :A组先腔内 70 0cGy× 3次 / 3周 ,后外照 5 0Gy/ 5周。B组外照射 6 0Gy/ 6 2周 ,40Gy后加腔内 5 0 0cGy× 2次同时进行。C组单纯外照射 70Gy/ 7周。结果 1、3、5年生存率A组为 46 7%、2 1 7%、6 7%,B组 73 3%、38 3%、2 1 7%,C组 5 6 3%、2 6 3%、16 3%,1年生存率B组高于A、C两组 ,有显著差异 (P <0 0 5 )。结论 A组放射反应重 ,疗效差 ,不易采用。B组较为理想 ,远期疗效有所提高 ,是腔内加体外照射目前可行的一种治疗方法。
Objective To purpost high dose rate of esophageal carcionoma brachy therapy in time, dose and fractionation factor, To improve local control rate and survival rate.Methods From Apr 1992 to Feb. 1995, 200 patients were randomized into three groups: A Bgroups were 60 cases auepted brachytherapy plus radiotherapy C. group was radiotherapy alone. A group with brachytherapy(BT) 7Gy×3/3 weeks + radiotherapy(50Gy/5 weeks), B group with R60 Gy/6.2 wk +(BT)5Gy/×2after radiotherapy in 40Gy C group with 70Gy/7 weeks radiotherapy alone.Results The 1-3-5-year survival rates of A,B,C, groups were 46.7%,21.7%,6.7% and 73.3%, 38.3%,21.7% and 56.3%, 26.3%, 16.3% respectively. The 1-year survival rates in B group had a significant difference (P<0.05). with A and C groups.Conclusion Brachytherapy plus radiotherapy in B group is better way in esophageal carciinoma treatment.
出处
《陕西肿瘤医学》
2002年第1期19-20,共2页
ShanXi Oncology Medicine
关键词
食管肿瘤
外照射
腔内照射
临床疗效
放射疗法
esophageal neoplasms, radiotherapy
brachytherapy
treatmant analysis
