摘要
目的 回顾性分析体外结合腔内高剂量率放射治疗局部晚期直肠癌的近期疗效和毒副反应。方法 以体外照射和腔内高剂量后装治疗局部晚期直肠癌 ,体外照射用6 0 Co或 10MV -X线 ,三野等中心照射 ,盆腔总剂量 5 0～ 60Gy/5～ 6周 ,腔内高剂量率后装治疗与体外照射同期进行 ,按肠腔狭窄程度选用不同外径的施源器。结果 全组 64例病人经治疗肿瘤完全消失 (CR) 7例 ,肿瘤部分消退 (PR) 37例 ,1年生存率 60 9% ( 39/64)。疼痛缓解 94 7% ,止血率 10 0 %。近期毒副反应主要为腹泻 (Ⅰ～Ⅱ度 ) 82 8% ( 5 3/64)、(Ⅲ～Ⅳ度 ) 12 5 % ( 8/64)。结论 体外结合腔内放射治疗局部晚期直肠癌 ,可达到缓解症状 ,提高病人生活质量 。
Objective The retrospective analysis of the late therapeatic results and toxic side-effects of radiation in local advanced rectal cancer(LARC) treated by external radiation plus intraluminal high-dose-rate brachytherapy.Methods External radiation with 60 Co or 10MV-X tolal dose lasted 50～60Gy/5～6weeks.Intraluminal brachytherapy was adopted at the same time.Results The group inclucled 64 patients,the complete response(CR) rate amouhted to 7 cases and the part response (PR) 37 cases.The 1-year survival rate was 60.9%(39/64),the pain-relief rate 94.7% and the hemostasis rate 100%.The late radiation side-effects was mainly diarrhea(Ⅰ～Ⅱdegree)82.8%(53/64),(Ⅲ～Ⅳdegree)12.5%(8/64).Conclusions External radiation combined with intraluminal high-dose-rate brachytherapy in LARC is able to relieve symptom,improves patient′s life quality and extends life-span.
出处
《河南肿瘤学杂志》
2003年第2期148-149,共2页
Henan Journal of Oncology
关键词
直肠癌
体外放射治疗
高剂量率后装治疗
rectal cancer
external radiation
high-dose-rate brachytherapy
