摘要
目的 :探讨慢性乙型肝炎患者血清ICAM - 1、TNF -α和IL - 8水平与肝损害的关系。方法 :应用双抗体夹心酶联免疫吸附法 (ELISA)检测 6 1例慢性乙型肝炎患者血清可溶性细胞间粘附分子 - 1(sICAM - 1)、肿瘤坏死因子 (TNF -α)和白细胞介素 - 8(IL - 8)水平。结果 :慢性乙型肝炎患者血清ICAM - 1、TNF -α和IL - 8水平均明显高于对照组 (P <0 .0 1) ,且病情越重其升高越明显。结论 :慢性乙型肝炎患者血清ICAM -1、TNF -α和IL - 8水平可反映其肝损害程度。检测慢性乙型肝炎患者血清ICAM - 1、TNF -α和IL -
Objective:To investigate the changes and relationships between serum levels of soluble intercellular adhesion molecule-1 (sICAM-1),tumor necrosis factor-α(TNF-α) ,interleukin-8(IL-8) and liver injury in patients with chronic hepatitis B. Methods:Serum sICAM-1, TNF-α and IL-8 were measured in 61 patients with chronic hepatitis B and 28 healthy persons by double antibody sandwich ELISA mothod.Results:Serum levels of sICAM-1, TNF-α and IL-8 in patients with chronic hepatitis B were significantly increased, compared with those in healthy persons. The more severe the disease, the higher the serum levels.Conclusions:Serum levels of sICAM-1, TNF-α and IL-8 in patients with chronic hepatitis B may reflect the damage of liver. Examination of serum levels of sICAM-1, TNF-α and IL-8 in patients with chronic hepatitis B can be used to judge the patient's condition and prognosis.
出处
《中国现代医学杂志》
CAS
CSCD
2002年第2期39-40,共2页
China Journal of Modern Medicine
