摘要
目的探讨病毒性肝炎患者血清白细胞介素-6(IL-6)和肿瘤坏死因子(TNF-α)的浓度变化及其临床意义。方法对30例健康体检者和50例病毒性肝炎患者的血清采用放射免疫分析(RIA)测定IL-6和TNF-α的浓度,同期检测其HBVDNA。结果病毒性肝炎患者的IL-6和TNF-α水平显著高于正常对照组(P<0.01)。肝炎后肝硬化组显著高于慢性乙型肝炎组(P<0.01),HBVDNA阳性组显著高于HBVDNA阴性组(P<0.01)。结论病毒性肝炎患者IL-6和TNF-α的测定能反映机体免疫损伤状况,对判断患者病情和预后有一定的临床价值。
Objective To investigate the concentration and its clinical significance of serum Interleukin - 6 （ IL - 6） and Tumor Necrosis Factor a （TNF - α） in the patients with chronic viral hepatitis B, Methods Serum IL - 6 and TNF - α in 30 healthy person and 50 patients with chronic viral hepatitis B were determined by radioimmunoassay（RIA）, In addition, HBVDNA was determined by polymerase chain reaetion（PCR） at the same time. Results The results showed that the levels of serum IL - 6 and TNF - α in patients with chronic hepatitis B were markedly higher than that in control group, showing significant difference （ P 〈 0. 01）, The lev- els of IL - 6 and TNF - α in the group of cirrhosis after having viral hepatitis B was higher than that in viral hepatitis B group, And the levels of IL- 6 and TNF- a in the group positive for HBV DNA were also higher than that in the group negative for HBV DNA, showing significant difference （ P 〈 0. 01）. Conclusion The detection of serum levels of IL - 6 and TNF - α in patients with chronic hepatitis B may disclose immunological injury to the body and it is of certain value in judging the conditions of the patients and prognosis.
出处
《中国热带医学》
CAS
2006年第9期1559-1560,共2页
China Tropical Medicine
