杀菌/通透性增加蛋白(BPI)研究进展
摘要
杀菌 /通透性增加蛋白 (BPI)是人中性粒细胞中存在的一种碱性蛋白 ,它能与革兰氏阴性菌脂多糖 (LPS)结合 ,具有中和内毒素和杀灭细菌作用 ,在革兰氏阴性菌感染的治疗方面有良好的发展前景。本文主要就BPI的生理功能 。
出处
《微生物学免疫学进展》
2002年第1期61-64,共4页
Progress In Microbiology and Immunology
参考文献27
-
1[1]Weiss J, Elsbach P, Olsson I, et al. Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes[J]. J Biol Chem 1978,253: 2664-2672.
-
2[2]Gray PW, Flaggs G, Leong SR, et al. Cloning of the cDNA of a human neutrophil bactericidal protein[J]. J Biol Chem 1989 ,264:9505 -9509.
-
3[3]Weiss J, Muello K, Victor M, et al. The role of lipopolysaccharides in the action of the bactericidal/permeability-increasing neutrophil protein on the bacterial envelope[J]. J Immunol 1984, 132(6):3109-3115.
-
4[4]Caodici C, Chen S, Sidorczyk z, et al. Effect of lipopolysaccharide (LPS) chain length on interactions of bactericidal/permeability-increasing protein and its bioactive 23-kilodalton NH2-terminal fragment with isolated LPS and intact Proteus mirabilis and Escherichia coli [J]. Infect Immun 1994,62:259-265.
-
5[5]Weiss J,Elsbach P, Shu C, et al. Human bactericidal/permeabilityincreasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria[J]. J Clin Investig 1992,90:1122-1130.
-
6[6]Wilde CG, Seilhamer J, McGrogan M, et al. Bactericidal/permeability-increasing protein and lipopolysaccharide ( LPS )-binding protein. LPS binding properties and effects on LPS-mediated cell activation[J]. J Biol Chem 1994,269: 17411-17416.
-
7[7]Iovine NM, Elsbach P, Weiss J. An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N-and C-terminal domains[J]. Proc Natl Acad Sci USA 1997,94:10973-10978.
-
8[8]van der Schaft DW, Toebes EA, Haseman JR, et al. Bactericidal/permeability-increasing protein( BPI ) inhibits angiogenesis via induction of apoptosis in vascular endothelial cells[J]. Blood 2000,96( 1 ): 176-181.
-
9[9]Newman SL, Gootee L, Gabay JE, et al. Identification of constituents of human neutrophil azurophil granules that mediate fungistasis against Histoplasma capsulatum [J]. Infect Immun 2000,68(10): 5668-5672.
-
10[10]Gavit P, Better M. Production of antifungal recombinant peptides in Escherichia coli [J]. J Biotechnol 2000,79:127-136.
-
1李彦兵,桂祎,李进涛,李作生,史宪伟,张以芳.杀菌/通透性增加蛋白研究现状及应用前景[J].中国畜牧兽医,2009,36(9):29-34. 被引量：4
-
2徐俊杰,徐静,童贻刚,王海涛.重组BPI_(23)-Fcγ1融合蛋白在CHO细胞中的表达[J].生物工程学报,2001,17(5):587-589. 被引量：6
-
3彭海英,朱家勇.杀菌/通透性增加蛋白的研究现状及展望[J].医学综述,2006,12(1):1-3. 被引量：5
-
4祁克宗,程玉磊,涂健.鸡、猪BPI氨基端的基因克隆和鉴定[J].广西农业生物科学,2006,25(B09):110-114. 被引量：1
-
5徐俊杰,徐静,王海涛.杀菌通透性增加蛋白基因的克隆及在CHO细胞中的表达[J].微生物学报,2001,41(6):669-673. 被引量：4
-
6邓娟,孙伟,苏建荣.铜绿假单胞菌脂多糖对白念珠菌生物膜形成的影响[J].中国真菌学杂志,2016,11(6):337-340.
-
7黄晓燕.宫颈粘液的分泌和精子-宫颈粘液相互作用与克罗米芬关系研究进展[J].国外医学（计划生育分册）,1997,16(1):30-33. 被引量：10
-
8彭海英,马育华,梁洪伟,高春海,李公祥.杀菌/通透性增加蛋白23-人酸性成纤维细胞生长因子融合蛋白在CHO细胞中的表达及活性鉴定[J].中国药物与临床,2012,12(12):1558-1560.
-
9房国强.下呼吸道感染革兰阴性杆菌232株耐药性分析[J].中国误诊学杂志,2010,10(12):2917-2918.
-
10高恒,彭开松,祁克宗,江龙海.牛杀菌/通透性增加蛋白氮端基因克隆和序列分析[J].畜牧兽医科技信息,2008,24(7):19-21.
