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杀菌/通透性增加蛋白的研究现状及展望 被引量:5

Present Status and Prospect of the Research on Bactericidal/Permeability Increasing Protein
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摘要 杀菌/通透性增加蛋白(BPI)是一种主要存在于中性粒细胞内的阳离子抗菌蛋白,具有杀菌及中和内毒素作用,在革兰阴性菌感染的治疗方面有很好的应用前景。本文主要对BPI分子结构、生物学功能、作用机制及临床应用等方面的研究进展进行综述。 The bactericidal/permeability-increasing protein (BPI) is a cationic protein of neutrophilie granulocytes,whieh possesses antibacterial and endotoxin-neutralizing activity against Gram-negative bacteria. The therapeutic role of BPI in Gram-negative bacterial infections is of a good prospects. In this review, the molecule structure, biological function, functional mechanisms and clinical research so on of BPI were summarized.
出处 《医学综述》 2006年第1期1-3,共3页 Medical Recapitulate
基金 广东省2004年自然科学基金重点项目(04105449)
关键词 杀菌/通透性增加蛋白 革兰阴性菌 内毒素 Bacteicidal/permeability increasing protein Gram-negative bacteria Endotoxin
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参考文献16

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