摘要
以儿茶酚或取代儿茶酚为原料,利用Mannjch反应合成了11个未见报道的邻二酚型Mannich碱盐酸盐,初步药理实验表明:该类化合物对血小板聚集都有一定的抑制作用。
Eleven catechol's Mannich bases HCl were designed & synthesized for pharmacological experiments according to structure of 'Danshansu'. These compounds which were never reported before were obtained by the well known Mannioh reaction, that is by the condensation of cateohol, 3, 4-dihydroxyace-tophenone respectively with formaldehyde and a series of secondary amines. The chemical structures of these new compounds were confirmed by means of 1HNMR spectrum and elementary analysis. The Pharmacological experiments showed that most of these compounds were effecctive for inhibition of ADP-induced rabbit platelet aggregation.
出处
《上海医科大学学报》
CSCD
1991年第1期67-71,共5页
Journal of Fudan University(Medical Science)
基金
本课题获得卫生部基金资助
