摘要
目的 评价丙肝宁冲剂治疗慢性丙型肝炎的疗效及安全性。方法 94例慢性丙型肝炎随机分为丙肝宁治疗组 (A组 ,32例 ) ,联合治疗组 (B组 ,干扰素α-1b加病毒唑 ,30例 ) ,单用干扰素组 (C组 ,32例 )。B、C 2组为对照组。分别观察治疗 2 6周、停药 2 6周时的临床症状体征改善情况 ,血清丙氨酸转氨酶 (ALT)的复常率 ,血清HCV RNA的阴转率。结果 A、B、C 3组治疗结束时的临床症状体征缓解率分别为 1 0 0 %、96 .6 %、90 .6 %。ALT复常率分别为 5 9.4 %、70 %、4 6 .9% ,停药观察 2 6周时 ,ALT持续复常率分别为 4 0 .6 %、5 0 %、2 5 % ,B组与C组之间比较有显著性差异 ,P <0 .0 5 ;HCV RNA的阴转率分别为 5 3.1 %、6 3.3%、37.5 % ,HCV RNA持续阴转率分别为 34 .4 %、4 6 .6 %、1 8.8% ,只有B组与C组之间比较有显著性差异 ,P <0 .0 5。结论 丙肝宁冲剂有明显抗丙型肝炎病毒疗效 ,且耐受性好 ,无严重不良反应 ,可成为慢性丙型肝炎治疗的有效方药之一。
OBJECTIVE To evaluate the therapeutic effect and safety of Bingganning Granule in the treatment of chronic hepatitis C. METHOD Ninety-four patients with chronic hepatitis C were divided into three groups: Bingganning Granule treatment group (Group A, 32 patients), comprehensive treatment group (Group B, treated with interferon α-1b and ribavirin, 30 patients) and simple interferon group (Group C, 32 patients). Changes in the clinical symptoms, ALT recovery rate and HCV-RNA negative rate were observed 26 weeks after the treatment was given and 26 weeks after the withdrawal of the medicine respectively. RESULT The remission rates of the symptoms and signs in Groups A, B and C were 100%, 96.6% and 90.6% respectively, the ALT recovery rates were 59.4% , 70% and 46.9% respectively, the ALT recovery rates 26 weeks after the withdrawal of the medicines were 40.6%, 50% and 25% respectively, with marked difference between Groups B and C ( P <0.05). HCV-RNA negative rates were 53.1%, 63.3% and 37.5% respectively and continuous HCV-RNA negative rates were 34.4%, 46.6% and 18.8% respectively, with marked difference between Groups B and C ( P <0.05). CONCLUSION Bingganning Granule has satisfactory effect against hepatitis C virus with good endurance and no side-effects, and therefore can be used in the treatment of chronic hepatitis C.
出处
《南京中医药大学学报》
CAS
CSCD
2002年第1期21-23,共3页
Journal of Nanjing University of Traditional Chinese Medicine
基金
国家九五攻关项目协作课题 ( 96 -90 6 -0 8-0 4)
关键词
丙型肝炎
丙肝宁冲剂
疗效
安全性
hepatitis C
Bingganning Granule
therapeutic effect
safety
