摘要
目的：研究壳聚糖－恶丙嗪缓释片的制备、质量标准，并考察体外释药性能。方法：采用紫外分光光度法测定主药恶丙嗪的含量。结果：线性范围为２．５～１５．０ｕｇ／ｍｌ，平均回收率为９９．７９％，ＲＳＤ为０．３８％。结论：该制剂制备工艺简单，值得临床推广应用。
OBJECTIVE: To study the preparation and quality standard of chitosan-oxaprozin sustained release tablets, and observe the rule of in vitro release of oxaprozin. METHODS:The content of oxaprozin in the tablets was determined by UV - spectrophotometry. RESULTS:The linear range was 2. 5- 15. 0ug/ml. The average recovery was 99. 79% with a RSD of 0. 38%. CONCLUSION: The preparation process of chitosan-oxaprozin sustained release tablet is simple. It is worth expanding the app- lication in clinical practice.
出处
《中国药房》
CAS
CSCD
2001年第9期532-533,共2页
China Pharmacy
关键词
壳聚糖
恶丙嗪
缓释片
质量控制
制备
chitosan
oxaprozin
sustained release tablet
preparation
quality control
