摘要
目的 :观察酸性成纤维生细胞长因子 (aFGF)对大鼠胃粘膜溃疡愈合的影响。方法 :用醋酸酐诱发大鼠胃粘膜溃疡建立动物溃疡模型 ,以aFGF多克隆抗体作为抗体通过免疫组化方法观察aFGF在溃疡区的表达情况。结果 :aFGF在溃疡区肉芽组织细胞浆中有高度表达 ,aFGF使溃疡区中微血管数目明显增加。结论 :aFGF通过促进血管生成 ,及内皮细胞 成纤维细胞、平滑肌细胞。
Objective: The paper was to observe the effect of acidic fibroblast growth factor(aFGF) on gastric ulcer healing. Methods: Animal model of gastric ulcer of rats was induced by acetic anhydride. Immunohistochemistry by polyclonal antibody against aFGF was used to explore the expression of aFGF in granulation tissues in the ulcer region. Results :aFGF has high expression at cytosol of fibroblast,endothelium and increases capillary density in granulation tissues of ulcer. Conclusion: aFGF possessed obvious curative effect on gastric ulcer by promoting angiogenesis and proliferation of endothelial cell,fibroblast, smooth muscle cell and collagen.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2002年第1期9-10,14,共3页
Journal of China Medical University
基金
辽宁省科技基金资助项目 (972 2 2 8)
