摘要
应用双抗体夹心ＥＬＩＳＡ和间接ＥＬＩＳＡ法检测１３２例心血管病患者（高血压病、冠心病、风湿性心脏病）血清中酸性成纤维细胞生长因子（ａＦＧＦ）和抗心磷脂抗体（ＡＣＡ）水平。结果表明，风湿性心脏病、高血压病、冠心病患者ＡＣＡ阳性率分别为２６．３％、２３．７％、１６．１％，均较对照组显著增高（Ｐ＜０．０１或Ｐ＜０．０５）。各种心血管病患者三种Ｉｇ类ＡＣＡ阳性检出率无显著差异，且存在一定程度的ａＦＧＦ水平升高。其中尤以ＡＣＡ阳性者为甚（Ｐ＜０．０１）。ＡＣＡ与ａＦＧＦ水平的升高有一定伴随，提示ＡＣＡ可能是诱发ａＦＧＦ水平增高的重要因素之一。
Using double antibody sandwich ELISA and indirect ELISA,we detected the level of acid fibroblast growth factor(aFGF)and anticardiolipin antibodies(ACA)in sera of 132 patients with cardiovascular disease(hypertension,rheumatic heart disease and coronary heart disease).The results indicated that the positive rates of ACA in patients with rheumatic heart disease,hypertension and coronary heart desease were 26 3%、23 7% and 11 1% respectively,and they were significantly higher than that in control groups(P<0 01 or P<0 05).No significant difference was found among the positive rates of three classes Ig ACA. There existed a certain degree rise of aFGF in patients with various cardiovascular diseases. The positive for ACA was the highest among them(P<0 01).It suggested that risen level of aFGF was associated with ACA,and ACA could be a important factor inducing the rise of aFGF.
出处
《临床检验杂志》
CAS
CSCD
北大核心
1997年第4期209-211,共3页
Chinese Journal of Clinical Laboratory Science
关键词
抗心磷脂抗体
心血管疾病
ELISA
AFGF
Fibroblast growth factor Anticardiolipin antibodies Cardiovascular disease Eneyme Linked immunosorbent assay
