摘要
目的 探讨Ⅰ期乳腺癌患者淋巴结、骨髓微小转移癌 (LNM、BMM )与临床预后因素的关系。方法 分别以抗上皮细胞膜单克隆抗体为探针 ,对 5 2例Ⅰ期乳癌中LNM ,BMM进行研究。结果 分别有 2 3%( 12 / 5 2 ) ,19.2 %( 10 / 5 2 )病例伴有LNM、BMM。在低分化乳癌组中 ,LNM( 4 5 .0 %,9/ 2 0 )或BMM( 35 .0 %,7/ 2 0 )阳性率明显高于高分化组 ( 9.3%,3/32 ;9.3%,3/ 32 ) (P <0 .0 1;<0 .0 5 )。在LNM阳性组中 ,BMM阳性率 ( 5 8.3%,7/ 12 )明显高于阴性组 ( 7.5 %,3/ 40 ) (P <0 .0 1)。结论 采用免疫组织化学技术可大大提高乳癌微小转移检出率 ,乳癌淋巴道 ,血道转移可同时发生。
Objective To explore lymph node and bone marrow micrometastases(LNM,BMM) and its relationship with clinical parameters.Methods LNM and BMM in 52 cases of breast cancer with stage Ⅰwere examined by immunohistochemical staining using monoclonal anti-epithelial membrane antigen(anti-EMA).Results LNM was observed in 12 of 52 cases (23.0%) and BMM in 10 of 52 cases (19.2%).In the group of poorly differentiation,the positive rates of LNM or BMM were significantly higher than those of well differentiation (P<0.01,<0.05).In the group of LNM,the positive rate of BMM was significantly higher than that of negative group(P<0.01).Conclusion The data suggest that immunohistochemical technique can greatly facilitate the detectability of micrometastases.The LNM and BMM may occur at the same time in breast cancer.
出处
《中国肿瘤临床与康复》
2002年第1期9-10,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
乳腺肿瘤
淋巴结微小转移
骨髓微小转移
上皮细胞膜抗原
免疫组化
breast cancer
lymph node micrometastases
bone marrow micrometastases
epithelial membrane antigen
immunohistochemistry
