摘要
用直流伏安法（ＤＣＶ）、微分脉冲伏安法（ＤＰＶ）和循环伏安法（ＣＶ）在玻碳电极（ＧＣＥ）上研究了依沙吖啶（ＥＡＤ）在不同介质中的阳极伏安行为，发现在０．１ｍｏｌ／Ｌ氢氧化钠溶液中于０．３８ Ｖ（ｖｓ．Ａｇ／ＡｇＣｌ）左右产生一个良好的阳极氧化峰，浓度在 ０．０５～８０ｍｇ／Ｌ之间与其峰电流呈线性关系。用本法不需要分离，可直接测定药物制剂和加标尿样。ＲＳＤ为１．４％～２．７％（ｎ＝１０）。尿样中ＥＡＤ的回收率为８９％～９５％。探讨了ＥＡＤ在ＧＣＥ上的电极反应机理。
The anodic voltammetric behavior of ethacridine (EAD) in the presence of various electrolytes was studied by using linear potential sweep voltammetry, differential-pulse voltammetry and cyclic voltammetry at a glassy carbon electrode. In the medium of 0.1 mol/L NaOH solution, an oxidative peak of ethaeridine was obtained. The peak potential is at about 0.40 V (vs. Ag/AgCl). The peak current is linearly increased with the concentration of ethaeridine over the range of 0.05 similar to 80 mg/L. The method has been used for the direct determination of ethacridine in injection. The relative standard deviation (n = 10) is 1.4% similar to 2.7%. The recoveries of ethacridine in urine samples are 89% similar to 95%. The mechanism of the electrode reaction was also discussed.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2002年第1期34-37,共4页
Chinese Journal of Analytical Chemistry
