摘要
目的：探讨茶碱脉冲式控释微丸的处方组成和制备工艺。方法：采用多层包衣的方法，以体外释药时滞和释药速率为指标，经正交试验设计，筛选较佳的处方组成和工艺。结果：制得的脉冲控释微丸体外释药时滞为６ｈ左右，在６～９ｈ内释药在７５％～９５％，稳定性良好。结论：采用多层包衣的方法能够制得合适的茶碱脉冲式控释微丸。
Aim To prepare an orally applicable pulsatile controlled-release drug delivery system in multile layer coated pellets forms using theophylline as a model drug.Methods The orthogonal experimental design method was used to optimize the formulation of the pellets of theophylline.Results The pellets of theophylline were prepared with about 6 hours lag time. The pellets were stable under the condition of 37℃,RH 75%.Conclusion The pulsatile release characteristics of the theophylline pellets in vitro were observed.
出处
《解放军药学学报》
CAS
2000年第1期17-20,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
茶碱
脉冲式控释
微丸
制备
中药
Theophylline
Pulsatile controlled-release
Pellets
In vitro
