摘要
为了简化无创的脑血流的定量方法 ,我们应用计算机仿真技术和以脉冲函数作为房室模型的输入函数 ,计算了 2 4例患者脑 99m Tc- ECD时间 -放射性曲线的脑存积分数。结果表明 :二室模型的脑存积分数 R2和三室模型的脑存积分数 R3在 α=0 .0 1水平上显著相关 ,相关系数为 0 .983 6;用 R2和 R3计算脑血流量分别为 2 9.4 8± 1.5 1和 2 9.10± 1.4 8ml/ min/ 10 0 g,两者之间无显著性差异 ( P>0 .0 5 ,n=2 4 )。这表明我们所提出的简化后的二室模型能够较好地刻划 99m Tc- ECD在脑内的分布机制 。
In order to simplify the non-invasive quantitative evaluation of cerebral blood flow (CBF), we used computer simulation and adopted the pulse function as the input function of compartment model for calculating the mean retention fraction of 99mTc-ECD in brain from the time activity curves(n=24). We found that there is a significant correlation between R2 (the retention fraction) from the 2-compartment model and R3 from the 3 compartment model with a correlation coefficient of 0.9836. The CBF by R2 is 29.48±1.51 ml/min per 100g, the CBF by R3 is 29.10±1.48 ml/min per 100g, and no significant difference between them is seen (P>0.05, n=24). These data indicate that the simplified two-compartment model for the mechanism of the uptake of 99mTc-ECD in brain is better. And we found that, compared with the entricular function, the pulse function may be used as a more appropriate input function for the model.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2001年第4期595-598,共4页
Journal of Biomedical Engineering
关键词
脑血流
定量分析
二房室模型
仿真
脑房室模型
Blood
Computer simulation
Correlation methods
Noninvasive medical procedures
