摘要
确定利用强脉冲磁场刺激 SD大鼠的脑部 ,是否可以引起内源性痛觉调制系统的兴奋产生镇痛作用。应用 CADWEL L MES- 10型刺激仪进行刺激 ,采用辐射热甩尾测痛法测量痛阈的变化。刺激参数 :( 1)强度百分比2 0 % ,刺激时间 7min。( 2 )强度百分比 3 0 % ,刺激时间 3 m in。在两种刺激参数作用后 ,平均痛阈变化率分别为 2 3 %和 2 6% ,痛阈的变化显著 ( P<0 .0 1,t检验 )。结果表明 :强脉冲磁场刺激大鼠脑部是一种有效的镇痛方法 ,和其他刺激镇痛方法相比 ,具有无痛。
The Objective of this study was to determine whether stimulation on the brain of SD rats with strong pulsed magnetic field could produce analgesic effect. A stimulator of CADWELL (MES-10) was adopted inthe study. The pain index used was the Tall Flick Latency (TFL) of rats. The stimulation parameters were, (1) the intensity percent (20%) and stimulation duration(7 min); (2) the intensity percent(30%) and stimulation duration(3 min). The results showed that the mean Acquired TFL change was 23% (P [less-than or equal to] 0.01) for the 20% intensity group, and 26% (P [less-than or equal to] 0.01) for the 30% intensity group. Conclusion: These data indicate that the new method for analgesia is effective, and compared with other approaches to stimulation analgesia, this one is non-invasive, easy to operate, and less causative of discomfort.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2001年第4期552-553,572,共3页
Journal of Biomedical Engineering
关键词
镇痛
内源性镇痛系统
脉冲磁场
大鼠
Analgesia Endogenous system of control of pain Pulsed magnetic fields
