摘要
DNA疫苗的安全性问题主要有三个方面 :转入体内的外源DNA有可能整合到宿主细胞基因组上 ,使宿主细胞抑癌基因失活或癌基因活化 ,使宿主细胞转化成癌细胞 ;外源抗原持续表达产生的不良后果 ;质粒DNA诱导的自身免疫反应。
Three major issues have been raised with respect to the safety of DNA vaccines .These are the potential for inducing a transformational event, possible unexpected adverse consequences of the persistent expression of a foreign antigen and the formation of anti?DNA antibodies. The review based on the relevent research articles give a summary of knowledge of DNA vaccines' safety published during past years.
出处
《生物技术通讯》
CAS
2001年第1期55-59,共5页
Letters in Biotechnology
