摘要
目的:光、电镜观察超量米非司酮对大鼠卵巢中卵泡、间质腺等细胞微细结构的改变。方法:给实验大鼠米非司酮10mg/只/d,分别用药7、14、28d,取材,制备标本,光、电镜观察。结果:多数卵泡在生长卵泡期间闭锁、部分闭锁卵泡形成间质腺,腺细胞内含大量脂滴、空泡,散在的溶酶体,线粒体包统脂滴,有板层体出现,巨噬细胞内出现巨大包含体,超微病理改变随用药时间延长有加重趋势。结论:超量米非司酮对卵泡发育有抑制作用,对卵泡的细胞、间质腺细胞有一定的损害。
Objective : To observe the ultrastructural changes of the cells of follicles and interstitial gland under the light and electron microscope by giving overdosage of mifepristone intragastrically. Method:Mifeprestone was given intragastrically to three groups of rats at a dose of 10mg/ml/d,after the rats were administrated for 7,14 and 28 days respectively. The rats were killed,the specimen was made fron the follicles and interstitial gland and observed under the light and electron microscope. Results:The majority of growth follicles was closed and formed into the interstitial gland. A large number of lipid droplets,vacuoles and secondarg lysosomes were present in the glandular cells. Some lipid droplets were rounded concentrically by mitochondria in 3-4 layers. The lamella were also presented in the gland cells. Huge lysosomes and remnant body-like structures appeared in macrophage. The pathological alterations exacerbated gradually with prolongation of administrational time. Conclusion: The growing of follicles can be inhibited by taking overdosage of mifepristone and the cells of follicles and interstitial gland can be changed pathologically by taking overdosage of mifepristone.
出处
《中国计划生育学杂志》
2001年第4期215-218,共4页
Chinese Journal of Family Planning
关键词
米非司酮
卵泡
间质腺
微细结构
Mifeprestone Follicles Interstitial gland Ultrastructures Ovary
