摘要
目的 :电镜下观察超剂量米非司酮对大鼠子宫内膜上皮细胞超微结构的影响 ,为进一步扩大米非司酮临床使用范围提供形态学依据。方法 :实验组大鼠每日灌胃饲服米非司酮 15mg/ ml/ d,用药 7d、14d、2 8d,取子宫 ,超薄切片 ,TEM观察。结果 :子宫内膜纤毛细胞纤毛减少 ,分泌细胞核可见核袋或假包含体 ,胞质发育较差 ,各种细胞器较少 ,可见大包含体 ;腺细胞次级溶酶体增多 ,有较多散在的糖原颗粒。结论 :超剂量使用米非司酮会使子宫内膜上皮细胞发育迟缓 。
objective:To provide reliable morphological basis for widening the range of using mifepristone clinically,the effects of taking overdosage mifepriston on ultrastructural changes about endometrial epithelium were observed under the TEM.Methods:15mg mifepristone was given intragastrically to each experimental rats in three groups,after this three groups rats were treated for different period of time 7,14 and 28 days,killed the rats,taken out the endometrium and made sections of it into the ultrathin sections,observed under TEM.Results:The cilia reduced from ciliated cells in numbers,some normal organella were lost,the crevices or interneuclear pseudoinclusion occurred in the secreting cells nuclear.Cytoplasmic processes,secreting granules and macro inclusions appeared,The second lysosomes increased,more scattered glycogen granules spread in the cytoplasm,but the glycogenic patch was seldom observed.Conclusion:Taking overdose mifepristone can cause the endometrial epithelium to became hypoevolutism.The progesterone receptor may be existed in epithelial cells.
出处
《承德医学院学报》
2001年第2期85-87,共3页
Journal of Chengde Medical University
基金
河北省计划生育委员会资助课题 (940 3)
