摘要
目的 :探讨胃粘膜异型增生中医微观辨证分型与胃癌MG7抗原表达及临床随访结果的关系。方法 :应用中医脏腑辨证理论与ABC免疫组化方法 ,对 12 0例胃粘膜异型增生进行内镜下微观辨证分型 ,并与胃癌MG7抗原表达的关系进行免疫组化分析 ,同时进行临床随访研究。结果 :胃络瘀滞型与胃络灼伤型胃粘膜MG7抗原表达阳性率 (37 5 %、6 6 7% )较胃寒型及胃热型 (6 7%、12 5 % )明显增高 ,差异有非常显著性意义 (P <0 .0 1)。对其中6 3例进行了 6～ 72个月 (平均 2 4个月 )的随访 ,癌变组中胃络瘀滞型粘膜 (2 3/ 30 )明显高于未癌变组 (9/ 33) ,差异有非常显著性意义 (P <0 .0 1)。结论 :中医微观辨证分型对辨别胃粘膜异型增生的癌变性质具有重要意义 ,胃络瘀滞型胃粘膜异型增生与癌变关系密切。
Objective:To study the relationship between microcosmic syndrome type of gastric dysplasia and the expression of MG7 antigen and its significance in follow up study.Methods:120 cases of gastric dysplasia were divided into four types by endoscopies according syndrome differentiation on Zang Fu organs theory of traditional Chinese medicine.The expression of MG7 antigen was studied by using ABC immunohistochemical method.Results:The expression of MG7 antigen in the Type Gastric collateral stasis(TGCS) and Type Burning Gastric Collateral(TBGC)(37.5%?66.7%)were higher than that of the groups of Type Gastric Cold(TGC)and Type Gastric Hot(TCH)(6%?12%)(P< 0.05～0.01 ).Sixty three cases were followed up for 6 to 72 month.There were 23 cases of TGCS in the 30 cases of cancer formation group,but nine in 33 cases of no cancer formation group(P< 0.01 ).Conclusion:The gastric dysplasia with TGCS has a close relationship to cancer formation.
出处
《中国中西医结合消化杂志》
CAS
2001年第6期325-327,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金资助课题 (No .89170 0 2 4 )
关键词
中医微观辨证
胃癌
异型增生
抗体单克隆
microcosmic differential diagnosis
gastric tumor
dysplasia
antibody monoclonal
