摘要
为观察枫蓼肠胃康颗粒对非特异性和脾虚型溃疡性结肠炎豚鼠的血中E -玫瑰花环形成率 (Ea -RFC)、总E -玫瑰花环形成率 (Eτ -RFC)、溃疡个数、溃疡面积和水肿面积变化的影响 ,将杂毛豚鼠分成 6组 ,每组 10只 ,用二硝基氯苯Ⅰ、Ⅱ、Ⅲ液注入肠管法和番泻叶灌肠法 ,分别建立豚鼠慢性非特异性结肠炎和脾虚型溃疡性结肠炎动物模型 ,在 0、2 1d取血测定血中Ea -RFC及Eτ -RFC含量 ,脾虚动物于给药 7d处死 ,计出各组动物溃疡个数、溃疡面积和水肿面积 .结果表明 :各剂量给药组中的Ea -RFC、Eτ -RFC免疫指标较造模组升高 (P分别<0 .0 1和 <0 .0 5 ) ,受试药高、中剂量组溃疡个数、溃疡面积、水肿面积较造模组降低 (P分别 <0 .0 1和 <0 .0 5 ) .提示 :枫蓼肠胃康颗粒对豚鼠非特异性结肠炎和脾虚型溃疡性结肠炎有显著疗效 .
In order to observe the influence of Fengliao Changweikang granule on the forming rate of Ea-rosette and Eτ-rosette in guinea pigs'blood,and on the numbers and area of ulcer,the area of edema of the guinea pigs which suffered from the nonspecific colitis and the ulcerative colitis with the insufficiency of the spleen,the animal models of the chronic nonspecific colitis and the ulcerative colitis with the insufficiency of the spleen were made by dividing guinea pigs into 6 groups(10 pigs each group) and by infusing the solution of 2,4-dinitrochlorobenzene Ⅰ,Ⅱ,Ⅲinto the intestinal canal and the senna leaf enema.At the 0 d,21st d,the contents of the Ea-RFC and Eτ-RFC in blood were determined.The guinea pigs with the insufficiency of the spleen were killed at the 7 th d after admistered medicine; the numbers of ulcer were counted and the area of ulcer and edema were measured.The results showed that Ea-RFC and Eτ-RFC immune indexes of each dosage group were higher than that of model group( P <0.01 and <0.05 respectively);the ulcer numbers,ulcer area and edema area of large and middle dosage groups were lower than that of model group( P <0.01 and <0.05 respectively).Thus a conclusion was drawn that Fengliao Changweikang Granule had an obvious curative effect on guinea pigs' nonspecific colitis and ulcerative colitis with the insufficiency of the spleen.
出处
《海南大学学报（自然科学版）》
CAS
2001年第4期366-369,共4页
Natural Science Journal of Hainan University
