摘要
[目的]观察理肠汤灌胃结合溃疡灵灌肠治疗大鼠实验性溃疡性结肠炎(UC)的疗效。[方法]将动物随机分为正常对照(正常)组、模型组、中药治疗小剂量(小剂量)组、中药治疗大剂量(大剂量)组、柳氮磺吡啶(SASP)组。其中除正常组外,其余4组均采用2,4,6-三硝基苯磺酸(TNBS)溶液制作大鼠模型,成功后大、小剂量组分别予大、小剂量理肠汤灌胃及溃疡灵灌肠;SASP组予SASP溶液灌胃,各组灌药时间均为14 d。[结果]大剂量组肠黏膜组织学损伤评分显著低于模型组(P<0.01);小剂量组、SASP组肠黏膜组织学损伤评分亦低于模型组(P<0.05),但小剂量组和SASP组疗效相近(P>0.05)。[结论]理肠汤灌胃结合溃疡灵灌肠治疗大鼠实验性UC有明显疗效。
[Objective]To observe and study the effects of the treatment on experimental rats with UC through orally taking Lichang Soup and clystering Kuiyang Ling.[Methods]Rats were divided randomly by weight into 5 groups：the control group,the model group,group treated with small dose of Chinese medicine,group treated with high dose of Chinese medicine and the SASP therapy group.Except the normal group,the other four groups used 2,4,6-TNBS liquor to make the rat model.After that,different treatments were given to different groups for 14 days：the high dose group and the small group were given respectively with high dose,small dose Lichang Soup to do gastric irrigation and Kuiyang Ling to do clyster,and the SASP group was given SASP liquor to do gastric irrigation.[Results]The histology injury score of intestinal mucosa of the group treated with high dose of Chinese medicine was lower than that of the model group obviously（P〈0.01）.The histology injury score of intestinal mucosa of the group treated with small dose of Chinese medicine and group treated with SASP were also lower than model group（P〈0.05）.But the treatment effect between the two groups was similar（P〉0.05）.There was no statistical significance between the two groups.[Conclusion]The treatment of Lichang Soup to do gastric irrigation combined with Kuiyang Ling to clyster have obvious effect on experimental rats with UC.
出处
《中国中西医结合消化杂志》
CAS
2010年第1期21-23,26,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
深圳市科技计划项目(200603246)
关键词
结肠炎
溃疡性
中医药治疗
理肠汤
溃疡灵
colonitisu, ulceration
Chinese medicine treatment
Lichang Soup, Kiuyang Ling
