摘要
目的:研究中医经典名方乌梅丸及加味方治疗UC在抗炎药效机理方面的中医方证相应依据。方法:建立大鼠UC两种类型模型,用研究方干预,取结肠病变组织,用ELISA法测定与抗炎药效密切相关因子IL-6、IL-10、TNFα和PGE2及用Westen Bloting法测定ICAM-1表达程度。结果:大鼠化学性刺激模型中乌梅丸、乌梅丸加味、芍药汤均影响相关因子(P<0.01,P<0.05),具有一定的抗炎药效,但各复方间差异不显著;而在大鼠免疫化学性复合模型中乌梅丸及加味方均明显影响和调节不同因子,其强度有显著性差异(P<0.01,P<0.05),同时ICAM-1表达程度也有差异。结论:乌梅丸及加味方和芍药汤在抗炎药效及机理方面存在一定程度的中医方证相应关系。
Objective：To explore the mechanisms of Wumeiwan and ad-prescription to cure Ulcerative Colitis in rats for FANG-ZHENG Correspondence of TCM theory.Methods：To establish two UC model in rat,while the experiment ends to take the pathological tissue of colon,to determine IL-6,IL-10,TNFα AND PGE2 by ELISA method,to observe ICAM-1expression by Westen Bloting.Results：Wumeiwan,ad-wumeiwan and Shaoyaotang have all to effect correlation factor and to pharmacodynamic action in model of Chemical irritation,but they are not differences.Other model of immunochemistry,Wumeiwan and ad-wumeiwan have to effect correlation factor and in pharmacodynamic action of strength are significant differences（P〈0.01,P〈0.05）.Meanwhile,ICAM-1 expression are also variance.Conclusion：Wumeiwan,ad-wumeiwan and Shaoyaotang have to be present FANG-ZHENG Correspondence of TCM theory in anti-inflammatory actions and the mechanisms.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2010年第8期677-679,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
中国中医科学院基本科研业务费自主选题(YZ-2006018)
关键词
乌梅丸
乌梅丸加味方
溃疡性结肠炎
抗炎药效
方证相应
Wumeiwan
ad-wumeiwan
Ulcerative Colitis
anti-inflammatory action
FANG-ZHENG Correspondence
