摘要
目的 探索一氧化氮 (NO)及血小板活化异常与糖尿病肾病 (DN)的关系。方法 74例 2型糖尿病 (DM)患者测定了血清 NO,其中 6 2例同时测定了血浆α-颗粒膜蛋白 (GMP140 )的水平 ,并依据 2 4小时尿白蛋白排出率(UAER)将其分为正常白蛋白尿组 (DM1 )、微量白蛋白尿组 (DM2 )、大量白蛋白尿组 (DM3 ) ,并与 37例正常人对照(NC)。结果 血清 NO在 DM1 较 NC明显升高 ,但 DM2 、DM3 却较 NC有显著性的降低 ;血浆 GMP140在 DM各组均较NC升高 ,特别是 DM2 、DM3 组较 NC明显升高。DM合并高血压者血 NO较无高血压者明显降低 ,而 GMP140均较无高血压者为高 (P<0 .0 5 )。血 NO与 GMP140呈显著负相关 (rs=- 0 .5 2 ,P<0 .0 5 )。结论 NO在 2型 DM早期升高 ,引起肾小球高灌注状态 ,后期下降 ,导致血小板活化增加。NO水平的异常及血小板活化的增强与 DN的发生。
Objective To explore the roles of nitric oxide(NO) and platelet activation abnormity in diabetic nephropathy(DN).Methods 74 type 2 diabetes mellitus(DM) patients were measured the levels of serum nitrites(NO - 2/NO - 3) a stable metabolic product of NO, and 62 among them were also determined the concentrations of GMP140(one of quota reflecting platelet activation) by ELISA. DM group were divided into three groups according to UAER(DM1: UAER <20ug/min, DM 2: UAER 20～200ug/min, DM3: UAER >200ug/min), and compared with 43 normal individuals(NC).Results Serum nitrites in DM1 were significantly higher than NC, but the NO levels of DM 2 and DM 3 were significantly lower than those; GMP140 in all of DM groups were higher than that in NC, espedaliy the DM 2 and DM3 were more increased than NC and DM1. NO in DM patients with hypertension were lower than that without hypertension, but GMP140 in DM patients with hypertension were higher than that without hypertension. There was significant negative correlation between NO and GMP140( r s=-0.52, P <0.05).Conclusion Elevated NO is related to renal hyperfiltration in early stage of DM. The decreased NO level in advanced DM may related to platelet activation, therefore promote the development of DN. The NO abnormity and the enbancement of platelet activation enhancement may be correlated with DN.
出处
《中国糖尿病杂志》
CAS
CSCD
2001年第6期337-340,共4页
Chinese Journal of Diabetes
关键词
糖尿病肾病
血小板活化
一氧化氮
Diabetic nephropathy Platelet activation Nitric oxide
