摘要
目的探索血小板活化异常与糖尿病肾病(DN)的关系。方法我们采用流式细胞术检测116例2型糖尿病(DM)患者周围血中CD+62p,CD+63,CD+31,CD+41及血浆α-颗粒膜蛋白(GMP140)含量测定(ELISA法),并依据24h尿白蛋白排出率(UAER)将其分为正常白蛋白尿组(DM1)、微量白蛋白尿组(DM2)、大量白蛋白尿组(DM3),并与40例正常人对照(NC)。结果周围血中CD+62p,CD+63,CD+31,CD+41及血浆GMP140在DM各组均较NC组升高,特别是DM2,DM3组较NC组明显升高。DM合并高血压者周围血中CD+62p,CD+63,CD+31,CD+41及血浆GMP140均较无高血压者为高(P<0.05)。结论血小板活化的增强可能与DN的发生、发展相关。
Objective To explore the relationship between platelet activation abnormality and diabetic nephropathy （DN） in type 2 diabetes mellitus （DM） patients. Methods 116 type 2 diabetes mellitus patients were measured of the levels of CD62p^＋,CD63^＋,CD31^＋,CD41^＋ and GMP140 （one of quota reflecting platelet activation） by flow cytometer. These patients were divided into three groups according to UAER levels： DM1 （UAER 〈 20 μg/min） , DM2 （UAER 20-200 μg/min） and DM3 （UAER〉200 μg/min） , and compared with 40 normal individuals （NC） . Results CD62p^＋,CD63^＋,CD31^＋,CD41^＋ and GMP140 in each patient group were higher than NC,especially those in DM2 and DM3 were significantly higher than NC. CD62p^＋,CD63^＋,CD31^＋,CD41^＋ and GMP140 in DM patients with hypertension were higher than those without hypertension （P〈0.05） Conclusion The enhancement of platelet activation may be correlated with DN.
出处
《云南医药》
CAS
2008年第1期6-8,共3页
Medicine and Pharmacy of Yunnan
关键词
糖尿病肾病
血小板活化
流式细胞术
Diabetic nephropathy
Platelet activation
Flow cytometer
