摘要
目的 考察麝香保心 p H依赖型梯度释药微丸的体外释放度。方法 分别以 HPMC,Eudragit○RL - 30 D- 5 5 ,Eudragit○RL 10 0 / S10 0为包衣材料制备 p H依赖型梯度释药微丸 ,以冰片和人参总皂苷为检测指标 ,按照《中国药典》2 0 0 0年版溶出度测定法 ,在模拟人体胃肠道 p H变化条件下进行释放度实验。结果 冰片和人参总皂苷释放度的f2 值为 79.6。
Object To investigate the release of pH dependent gradient releasing heart protecting musk pellets (GRHPMP) in vitro. Methods The pH dependent GRHPMP was prepared by coating with hydroxy propylmethy cellulose, Eudragit ○R L 30D 55 and Eudragit ○R L100/S100, repectively. The release of borneol and total ginsenoside from GRHPMP were determined according to method described in Chinese Pharmacopoeia (2000 ed) at simulated gastrointestinal pH conditions. Results The f 2 value of release data of borneol and total ginsenoside was 79 6. Conclusion The result suggested that, in vitro, the liposoluble borneol and watersoluble total ginsenoside could release simultaneously at a sustained rate.
出处
《中草药》
CAS
CSCD
北大核心
2001年第11期978-981,共4页
Chinese Traditional and Herbal Drugs
关键词
麝香保心pH依赖型梯度释药微丸
冰片
人参总皂苷
体外释放度
中药
pH dependent gradient releasing heart protecting musk pellets (GRHPMP)
borneol
total ginsenoside
in vitro release
